About Program 1
Title: Macrophages in Inflammatory Diseases
Macrophages adopt disease-specific patterns of shapes and functions called ‘phenotypes’.
The concept is to identify the fine control mechanisms that allow some macrophages to differentiate into disease causing phenotypes while preserving the essential functions of the non-disease causing phenotypes.
 Examination of this subtle plasticity of macrophages may help us find new classes of treatment for chronic inflammatory diseases, without hampering their normal biological functions.
Program 1 was designed to discover new disease-specific genes in macrophages and also to validate genes of interest. To achieve both of these things, researchers have developed sophisticated animal disease models and comprehensive tissue collections in both RA and COPD.
About Rheumatoid Arthritis
About Chronic Obstructive Pulmonary Disease | 
