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Our research publications

Here are some of our research publications:

Journal articles

• Cowieson N.P., King G., Cookson D., Ross I., Huber T., Hume D.A., Kobe B., Martin J.L. Cortactin adopts a globular conformation and bundles actin into sheets. J Biol Chem 2008a;283:16187-16193.
• Liu K., Gualano R.C., Hibbs M.L., Anderson G.P., Bozinovski S. Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection. J Biol Chem 2008b;283:9977-9985.
• Schroder K., Spille M., Pilz A., Lattin J., Bode K.A., Irvine K.M., Burrows A.D., Ravasi T., Weighardt H., Stacey K.J., Decker T., Hume D.A., Dalpke A.H., Sweet M.J. Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. J Immunol 2007;179:3495-3503.
• de Weerd N.A., Samarajiwa S.A., Hertzog P.J. Type I interferon receptors: biochemistry and biological functions. J Biol Chem 2007;282:20053-20057.
• Fleetwood A.J., Lawrence T., Hamilton J.A., Cook A.D. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007;178:5245-5252.
• Meadows N.A., Sharma S.M., Faulkner G.J., Ostrowski M.C., Hume D.A., Cassady A.I. The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. J Biol Chem 2007;282:1891-1904.
• Aung HT, Schroder K, Himes SR, Brion K, van Zuylen W, Trieu A, Suzuki H, Hayashizaki Y, Hume DA, Sweet MJ, Ravasi T. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB. J. 2006; 20:1315-27.
• De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA & Scholz GM. A central role for the Hsp90-Cdc37 molecular chaperone module in IRAK-1 dependent signaling by Toll-like receptors. Journal of Biological Chemistry, 280:9813-22. 2005.
• Roberts TL, Sweet MJ, Hume DA, Stacey KJ. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphoreothioate-modified oligonucleotides. Journal of Immunology; 174(2):605-8. 15 January, 2005.
• Hansen M, Bozinovski S, Vlahos R, Jones JE, Gualano R, Anderson GP. Therapeutic strategies to ameliorate skeletal muscle wasting in COPD. Journal of Pharmacol. Therapeut; 2005; 109(1-2):162-72
• Bozinovski S, Cross M, Vlahos R, Jones JE, Hsuu K, Tessier PA, Reynolds EC, Hume DA, Hamilton JA, Geczy CL, Anderson GP. S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 2005; 4: 136-45.

Book chapters

• Hume D.A., Schroder K., Irvine K.M., Carninci P. The impact of CAGE data on the understanding of macrophage transcriptional biology. In ‘CAGE’. 2008 (in press).
• Stacey K.J., Clark F., Young G.R., Roberts T.L. ., Ishii K.J., Akira S. Discrimination between self and non-self DNA. In Nucleic Acids in Innate Immunity.  CRC Press, FL, USA. (eds)  (in press). 2008
• Samarajiwa S., Wilson W., Hertzog P.J. ‘Type I Interferons: Genetics and Structure’ The Interferons: characterisation and application. Ed: A Meager, Wiley-VCH, Weinheim, Germany, pp3-34, 2006.
• Veil, M., Borg C., Cumming S. Biotechnology. Oxford University Press, August2007.

Some recent presentations by our staff:

• Cook A.D., Turner A.L., Braine E.L., Hamilton J.A. GM-CSF produced by lymphocytes is sufficient for development of collagen-induced arthritis. Australian Rheumatology Association Victorian Branch, Annual Scientific Meeting, February 2008.
• Cook AD, Braine EL, Massa CM, Turner AL, Way KJ, Beckman SK, Hamilton JA. Urokinase-plasminogen activator derived from bone marrow cells is required for collagen-induced arthritis induction. Australian Rheumatology Association 50^th Annual Scientific Meeting, Adelaide, May 2008.
• Grøndahl L., Chandler-Temple A., Cassady A.I., Kingshott P. In vitro protein adsorption and pro-inflammatory response to grafted membranes. World Biomaterials Congress, Amsterdam, Netherlands, May, 2008.
• Hamilton J.A. Colony stimulating factors and chronic inflammatory diseases.  Centenary Institute, NSW. April, 2007
• Hamilton J.A. Control of macrophage lineage phenotypes by colony-stimulating factors – implications for the inflammatory response. 8^th World Congress on Inflammation, Denmark. June, 2007
• Hamilton J.A. GM-CSF and M-CSF in inflammation and cancer. Garvan Institute, NSW. September, 2007
• Hamilton J.A. Markers of Chronic Inflammation. Australian Association of Clinical Biochemists (AACB) Annual Scientific Conference, Melbourne. September, 2007.
• Hamilton J.A. Potential Therapeutic Uses Of GM-CSF Autoantibodies. American Thoracic Society International Conference, Toronto, Canada. May, 2008
• Hamilton J.A. TAM contribution to breast cancer metastasis. National Breast Cancer Framework Workshop March, 2007
• Lacey D., Park D., Short B., Brouard N., Simmons P., Graves S., Hamilton J.A. TNF and IL-1 inhibits osteogenic differentiation of mouse mesenchymal stem cells in vitro: implications for bone repair during chronic inflammation. ARA Scientific Conference 2008
• Schroder K. A novel function for STAT1 in CpG DNA signalling in macrophages. Guest Seminar Series, Mater Medical Research Institute, Brisbane 2007

Find out more about our research

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